Long non-coding RNA HNF1A-AS1 up-regulation in non-small cell lung cancer correlates to poor survival.

OBJECTIVE Accumulating studies have focused on the role of the newly identified lncRNAs in the tumor. We aimed to investigate the clinical correlation between long non-coding RNA HNF1A-AS (HNF1A-AS1) expression and non-small cell lung cancer (NSCLC). PATIENTS AND METHODS Real-time polymerase chain reaction (PCR) was employed to detect HNF1A-AS expression in NSCLC tissues and corresponding adjacent tissues. The c2-test was used to compare the clinicopathological characteristics between different groups. Survival analysis was performed using the Kaplan-Meier method. The univariate and multivariate analyses were performed to investigate the prognostic significance of HNF1A-AS for NSCLC. RESULTS The level of HNF1A-AS was higher in tumor tissues than that in normal tissues (p < 0.01). In addition, HNF1A-AS level was significantly associated with TNM stage (p = 0.002) and Lymph node metastasis (p = 0.005). Kaplan-Meier analysis indicated that a high level of HNF1A-AS expression predicted unfavorable overall survival (p < 0.001). The univariate and multivariate analysis identified HNF1A-AS as an independent poor prognostic factor for overall survival in NSCLC patients (p < 0.05). CONCLUSIONS These results demonstrated that overexpression of HNF1A-AS might act a poor prognosis indicator in patients with NSCLC.